Understanding Rinvoq side effects is important for anyone considering this medication, Rinvoq (upadacitinib) helps manage inflammatory conditions like rheumatoid arthritis, eczema, and ulcerative colitis—but it can also cause side effects. Like all prescription medications, Rinvoq affects each person differently. Some side effects are mild and temporary, while others may require medical attention.
Still, many patients start Rinvoq without knowing what to expect. That’s why this guide explains the most common and serious side effects clearly—so you can make informed decisions, track your health, and talk to your doctor if anything feels off.
Common Side Effects
Many patients experience mild side effects when starting Rinvoq. These usually go away after your body adjusts to the medication.
- Upper respiratory infections: Cold-like symptoms such as stuffy nose, sore throat, or cough
- Headache: Often manageable with rest or over-the-counter pain relievers
- Nausea: Mild stomach discomfort, especially early in treatment
- Acne or rash: Skin irritation, more common in people with eczema
- Fatigue: Feeling tired or low on energy, usually temporary
If these side effects persist or worsen, let your healthcare provider know. They may adjust your dosage or offer ways to manage the symptoms.
More Serious Risks
In some cases, Rinvoq may lead to more serious side effects. These are less common but important to watch for.
- Infections: Rinvoq lowers immune response, increasing the risk of serious infections like pneumonia, shingles, or urinary tract infections
- Blood clots: Rare but serious risk, especially in the legs or lungs (deep vein thrombosis or pulmonary embolism)
- Heart problems: Increased risk of heart attack or stroke in some patients, especially those with existing risk factors
- Cancer risk: Some studies suggest a possible higher risk of certain cancers, including lymphoma
- Liver changes: Elevated liver enzymes that may show up in blood tests
If you experience chest pain, shortness of breath, swelling, unusual bruising, or signs of infection (fever, chills), stop using Rinvoq and contact a healthcare professional right away.
Who Should Be Extra Cautious
Certain patients face higher risks when using Rinvoq. Talk to your doctor before starting if you have:
- A history of serious infections
- Heart disease or stroke risk
- Cancer history or immune system disorders
- Liver problems or hepatitis
- Plans for live vaccines
Doctors often screen for tuberculosis (TB) and hepatitis before prescribing Rinvoq. Make sure your full health history is up to date.
Routine Monitoring and Blood Tests
While taking Rinvoq, your doctor may order regular blood work to check your:
- Liver enzymes
- Cholesterol levels
- White and red blood cell counts
These tests help catch problems early—even before symptoms appear. Keeping your follow-up appointments and labs on schedule is an important part of safe treatment.
Tips to Manage Side Effects
If you notice side effects, small changes can help you feel more comfortable while your body adjusts:
- Take Rinvoq with food to reduce nausea
- Drink plenty of water and rest if you feel fatigued
- Keep a symptom journal to share with your doctor
- Avoid contact with sick people to lower your infection risk
- Report new symptoms quickly—even if they seem unrelated
Open communication with your provider helps ensure safe, effective treatment.
Conclusion
In summary, Rinvoq helps manage chronic inflammation but comes with side effects that every patient should know about. Most are mild, but a few carry serious risks. Watch for infections, changes in how you feel, or anything unusual. Stay informed, follow up with your care team, and take steps to manage any side effects early.
By understanding what to expect and knowing when to call your doctor, you take an active role in your health—and make the most of your treatment with Rinvoq.